Enhanced Absorption Protectamins® Vegetables DIM-plus™ contains diindolylmethane, a phytonutrient found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale. Diindolylmethane has unique benefits that support the activity of enzymes that improve estrogen metabolism.* Research shows diindolylmethane increases the level of 'favorable' estrogens (2-hydroxyestrogen) while reducing the level of 'less favorable' estrogens (16-hydroxyestrogen).* Directions Women take 2 capsules daily with food. Men take 2 capsules twice daily with food. For intensive use (Women/Men): take up to double the recommended dose. Notes Keep out of reach of children. Indolplex® and BR-DIM® are registered trademarks of and are licensed from BioResponse, L.L.C., Boulder, CO. White Vegetarian Capsule Color protects DIM® from light Q: Why does DIM-plus™ use DIM and not I3C? A: Diindolylmethane (pronounced: dye-indo-leel-methane), or DIM for short, as well as indole-3 carbinol (I3C) are plant nutrients found in broccoli, cauliflower, cabbage, and other related vegetables. Research has shown that DIM improves the way estrogen and other reproductive hormones are metabolized in the body.* However, the research on I3C has been mixed, with some studies showing benefits and other studies having negative results.As a dietary supplement, DIM provides the exact compounds that are found in vegetables. It’s fully active and ready to be absorbed, while IC3 must first be synthesized into DIM after it’s digested. When combined with vitamin E and phosphatidylcholine, DIM is highly absorbable. IC3, on the other hand, has an unpredictable absorption rate. The stability of IC3 is very low compared to DIM’s, too. Some research has shown IC3 may cause certain side effects, including stomach upset and dizziness; DIM has no known side effects. Therefore, DIM-plus™ features active DIM. There is no I3C in the product.