The 7-Keto® metabolite of DHEA is a natural, non-steroidal molecule that is produced in the body from DHEA. This metabolite is chemically different from DHEA and cannot convert back into DHEA in the body. Studies indicate that 7-Keto may be useful in supporting healthy weight management while following an exercise program and healthful diet. ‡† During the normal aging process, natural levels of 7-Keto begin to decline. Research in animals also shows that aging may have an effect on the body’s ability to maintain optimum thermogenesis (fat burning) activity. Recent research indicates that 7-Keto may play important roles in supporting a healthy weight by activating thermogenic enzymes.‡† Several clinical studies have been conducted in healthy overweight adults. In one double-blind, placebo-controlled study, subjects given 200 mg of 7-Keto reduced body weight more significantly compared with placebo while maintaining a diet and exercise regimen. No significant changes in blood glucose, hormonal levels, liver enzymes or renal function were experienced and no adverse side effects were reported. In another double-blind, placebo-controlled study, after 8 weeks subjects on an exercise program and healthful diet lost significantly more weight compared with placebo. The natural metabolite 7-Keto was again well-tolerated, and no significant adverse effects were reported. Additional studies indicate that 7-Keto cannot convert into other steroid hormones in the body and does not affect estrogen, testosterone or progesterone levels in the body.‡