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However, a growing body of research highlights its important role in supporting other body systems, including cardiovascular and blood sugar balance as well as increasing musculoskeletal strength, neurological and immune function enabled by its ability to target over 200 different genes throughout the body. At the same time, deficiency and insufficiency of this important nutrient has reached epidemic proportions around the world, making the achievement of optimal levels extremely important to overall health.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e Known as the sunshine vitamin, one of the key roles of vitamin D is maintaining serum calcium and phosphorous balance. The body makes vitamin D by converting vitamin D2 to D3, or cholecalciferol, when exposed to sunlight. Vitamin D3 is also the form which the body derives from dietary cholesterol. 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In particular, these two plant sterols enhance the activity of the T-helper cells. The T-helper cells are arguably the most important cells in adaptive immunity, because they are required for almost all adaptive immune responses. The T-helper cells not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, they also help activate cytotoxic T cells to kill infected target cells. ModucareVET improves the ratio of T-helper 1 to T-helper 2 cells, and, as a result, the companion animal's cellular immunity is enhanced and overactive immune responses are down-regulated. The potential of Moducare® to optimize immune function in humans has been demonstrated in clinical studies.\u003cbr\u003e\u003cbr\u003eModucareVET also helps maintain a normal ratio of two hormones produced by the adrenal gland – cortisol and DHEA. An optimal balance of these hormones helps to buffer negative stress responses as they occur. 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In addition to psyllium, Fiber Plus includes rice bran for its glycemic balancing effects and pectin, a soluble fiber found in apples. Fig fruit and prune are also included because they contain natural compounds which act as mild colonic stimulants to relieve symptoms of occasional constipation. 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