NAD+ (nicotinamide adenine dinucleotide) is one of the most researched longevity molecules in science today. As levels naturally decline 40–50% between ages 20 and 60, replenishing NAD+ via its precursors NMN and NR has become a leading strategy in anti-aging medicine. Our NAD+ and longevity supplement collection brings together the most clinically studied compounds.

Why does NAD+ matter for aging? NAD+ powers over 500 enzymatic reactions, fuels mitochondrial energy production, activates sirtuin longevity proteins, and supports DNA repair mechanisms. Declining NAD+ is directly linked to fatigue, metabolic slowdown, cognitive decline, and accelerated cellular aging.

Top NAD+ and longevity compounds:

• NMN (Nicotinamide Mononucleotide) — direct NAD+ precursor; shown in human trials to raise NAD+ levels, improve insulin sensitivity, and support aerobic capacity
• NR (Nicotinamide Riboside) — alternative NAD+ precursor with strong human clinical data; raises blood NAD+ in 2–4 weeks
• Resveratrol — activates SIRT1 and SIRT3 sirtuins; works synergistically with NMN (Dr. David Sinclair protocol)
• Trans-Pterostilbene — more bioavailable than resveratrol; crosses blood-brain barrier; potent sirtuin activator
• Apigenin — inhibits CD38 (enzyme that degrades NAD+); helps sustain NAD+ levels between doses
• Fisetin — senolytic flavonoid; clears senescent "zombie" cells; extends healthspan in animal models

Peach Vitamins carries the most studied NAD+ and longevity formulas from Life Extension, Jarrow, NOW Foods, and Thorne — curated by nutrition professionals since 1999.