Manganese tends to concentrate in the mitochondria, as well as in the bones, liver, pancreas, and kidneys, and is an essential component of healthy carbohydrate metabolism, reproductive function, and skeletal and cartilage development.* Manganese supplementation supports connective tissue health, providing benefit for ligaments, tendons, joints, and muscles.* Manganese also supports the function of antioxidants as an essential cofactor for superoxide dismutase (SOD), an enzyme that protects cell membranes from oxidative damage.* Manganese Bisglycinate is a fully reacted mineral chelate that exhibits optimal absorbability.*

Manganese is a critical element in two metalloenzymes – pyruvate decarboxylase and superoxide dismutase – both of which are involved in energy production and immune function.* It also activates various enzymes that facilitate the synthesis of protein and DNA in the production of mucopolysaccharides that are found in cartilage.*

Manganese is an essential cofactor for superoxide dismutase (SOD), an enzyme that protects cell membranes from lipid peroxidation and other harmful processes; therefore, a manganese deficiency can contribute to an SOD deficiency.*